Article
Gene expression regulation by upstream open reading frames and human disease.
PLoS genetics - 1 Jan 2013
Barbosa Cristina, Peixeiro Isabel, Romão Luísa
Abstract excerpt
Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryotic mRNAs, one or more uORFs precede the initiation codon of the main coding region. Indeed, several studies have revealed that almost half of human transcripts present uORFs. Very interesting examples have shown that these uORFs can impact gene expression of the downstream main ORF by triggering mRNA decay or by...
Topics
- 5' Untranslated Regions
- Disease
- Gene Expression Regulation
- Genetic Association Studies
- Humans
- Mutation
- Open Reading Frames
- Protein Biosynthesis
- RNA Stability
- Regulatory Sequences, Nucleic Acid