Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2017

Jones Lataisia, Goode Lacy, Davila Eduardo, Brown Amber, McCarthy Deirdre M, Sharma Nutan, Bhide Pradeep G, Armata Ioanna A

Abstract excerpt

Upstream open reading frames (uORFs) have emerged as major post-transcriptional regulatory elements in eukaryotic species. In general, uORFs are initiated by a translation start codon within the 5' untranslated region of a gene (upstream ATG; uATG), and they are negatively correlated with translational efficiency. In addition to their translational regulatory role, some uORFs can code for biologically active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dystonic Disorders

Share to GTP Cyclohydrolase

Share to HEK293 Cells

Share to Open Reading Frames

Share to Polymorphism, Single Nucleotide

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 28366877
DOI: 10.1016/j.bbadis.2017.03.024
PMCID: PMC6766408

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia.PMID 28366877Read ↗

Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region.Semantic proximity Read ↗

Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct originSemantic proximity Read ↗

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read ↗

Gene expression regulation by upstream open reading frames and human disease.Semantic proximity Read ↗

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.Semantic proximity Read ↗

Role of 5'- and 3'-untranslated regions of mRNAs in human diseases.Semantic proximity Read ↗

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read ↗

A comprehensive catalog of predicted functional upstream open reading frames in humans.Semantic proximity Read ↗

An upstream open reading frame impedes translation of the huntingtin gene.Semantic proximity Read ↗

Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genomeSemantic proximity Read ↗

Microsatellite expansions hidden within the human dark genome are translated in novel and toxic proteins causing muscle and neurodegenerative diseasesSemantic proximity Read ↗

uORFlight: a vehicle towards uORF-mediated translational regulation mechanisms in eukaryotesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.