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Article

Some like it translated: small ORFs in the 5′UTR

17 Aug 2020

Abstract excerpt

The 5' untranslated region (5'UTR) is critical in determining post-transcriptional control, which is partly mediated by short upstream open reading frames (uORFs) present in half of mammalian transcripts. uORFs are generally considered to provide functionally important repression of the main-ORF by engaging initiating ribosomes, but under specific environmental conditions such as cellular stress, uORFs can become...

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PMID: 32818479
DOI: 10.1016/j.yexcr.2020.112229

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