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Article

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.

Developmental cell - 1 Aug 2007

Niwa Yasutaka, Masamizu Yoshito, Liu Tianxiao, Nakayama Rika, Deng Chu-Xia, Kageyama Ryoichiro

Abstract excerpt

Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe. Here, we show that Hes7 also regulates cyclic expression of the Fgf signaling inhibitor Dusp4 and links Notch and Fgf oscillations in phase. Strikingly, inactivation of Notch signaling abolishes the propagation but allows the initiation of Hes7...

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PMID: 17681139
DOI: 10.1016/j.devcel.2007.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.PMID 17681139Read ↗

Dynamic expression and essential functions of Hes7 in somite segmentation.Semantic proximity Read ↗

Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton.Semantic proximity Read ↗

Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.Semantic proximity Read ↗

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids.Semantic proximity Read ↗

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.Semantic proximity Read ↗

<i>In vitro</i> characterization of the human segmentation clockSemantic proximity Read ↗

Deciphering the somite segmentation clock: beyond mutants and morphants.Semantic proximity Read ↗

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