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Article

Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.

PloS one - 24 Nov 2009

Stauber Michael, Sachidanandan Chetana, Morgenstern Christina, Ish-Horowicz David

Abstract excerpt

Vertebrate segmentation is regulated by the "segmentation clock", which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM). One such gene is Lunatic fringe (Lfng), which encodes a modifier of Notch signalling, and which is also expressed in a stripe at the cranial end of the PSM, adjacent to the newly forming somite border. We have investigated the functional requirements for these...

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Source

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Identifiers

PMID: 19956724
DOI: 10.1371/journal.pone.0007996
PMCID: PMC2776510

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Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.PMID 19956724Read ↗

Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton.Semantic proximity Read ↗

Dynamic expression and essential functions of Hes7 in somite segmentation.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.Semantic proximity Read ↗

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.Semantic proximity Read ↗

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.Semantic proximity Read ↗

Defects in somite formation in lunatic fringe-deficient mice.Semantic proximity Read ↗

<i>Fgf4</i> is critical for maintaining <i>Hes7</i> levels and Notch oscillations in the somite segmentation clockSemantic proximity Read ↗

The role of presenilin 1 during somite segmentation.Semantic proximity Read ↗

Lunatic fringe promotes the lateral inhibition of neurogenesis.Semantic proximity Read ↗

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