Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton.

Abstract excerpt

The Notch pathway plays multiple roles during vertebrate somitogenesis, functioning in the segmentation clock and during rostral/caudal (R/C) somite patterning. Lunatic fringe (Lfng) encodes a glycosyltransferase that modulates Notch signaling, and its expression patterns suggest roles in both of these processes. To dissect the roles played by Lfng during somitogenesis, a novel allele was established that lacks...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Body Patterning
• Share to Bone and Bones