Article
NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids.
Genes & development - 2 Sept 2025
Meijer Hedda A, Hetherington Adam, Johnson Sara J, Gallagher Rosie L, Hussein Izzah N, Weng Yuqi, Rae Jess M, Noordzij Tomas E J C, Kalamara Margarita, Macartney Thomas J, Davidson Lindsay, Martin David M A, Gierlinski Marek, Davies Paul, Sonnen Katharina F, Murray Philip J, Dale J Kim
Abstract excerpt
The segmentation clock is a molecular oscillator that regulates the timing of somite formation in the developing vertebrate embryo. NOTCH signaling is one of the key pathways required for proper functioning of the segmentation clock. Aberrant NOTCH signaling results in developmental abnormalities such as congenital scoliosis as well as diseases such as T-cell acute lymphoblastic lymphoma (T-ALL). In this study,...
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