Article
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
PLoS genetics - 1 Sept 2009
Ferjentsik Zoltan, Hayashi Shinichi, Dale J Kim, Bessho Yasumasa, Herreman An, De Strooper Bart, del Monte Gonzalo, de la Pompa Jose Luis, Maroto Miguel
Abstract excerpt
Segmentation of the vertebrate body axis is initiated through somitogenesis, whereby epithelial somites bud off in pairs periodically from the rostral end of the unsegmented presomitic mesoderm (PSM). The periodicity of somitogenesis is governed by a molecular oscillator that drives periodic waves of clock gene expression caudo-rostrally through the PSM with a periodicity that matches somite formation. To date...
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