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Article

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.

Birth defects research. Part C, Embryo today : reviews - 1 Jun 2007

Sparrow Duncan B, Chapman Gavin, Turnpenny Peter D, Dunwoodie Sally L

Abstract excerpt

Somites are the precursors of the vertebral column. They segment from the presomitic mesoderm (PSM) that is caudally located and newly generated from the tailbud. Somites form in synchrony on either side of the embryonic midline in a reiterative manner. A molecular clock that operates in the PSM drives this reiterative process. Genetic manipulation in mouse, chick and zebrafish has revealed that the molecular...

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Source

Identifiers

PMID: 17600782
DOI: 10.1002/bdrc.20093

Genes

DLL3
LFNG
MESP2
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.PMID 17600782Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton.Semantic proximity Read ↗

Role of Delta-like-3 in mammalian somitogenesis and vertebral column formation.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine.Semantic proximity Read ↗

Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.Semantic proximity Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.Semantic proximity Read ↗

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids.Semantic proximity Read ↗

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoidsSemantic proximity Read ↗

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.Semantic proximity Read ↗

Reconstituting human somitogenesis <i>in vitro</i>Semantic proximity Read ↗

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