Article
Deciphering the somite segmentation clock: beyond mutants and morphants.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2007
Lewis Julian, Ozbudak Ertugrul M
Abstract excerpt
The regular pattern of somite segmentation depends on a clock, the somite segmentation clock, in the form of a gene expression oscillator, operating in the presomitic mesoderm (the PSM) at the tail end of the vertebrate embryo. Genetic screens and other approaches have identified a variety of genes, including components and targets of the Notch signalling pathway, that show transcriptional oscillations in this...
Topics
- Animals
- Biological Clocks
- Body Patterning
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mutation
- Somites
