Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.

Abstract excerpt

During vertebrate development, the presomitic mesoderm (PSM) periodically segments into somites, which will form the segmented vertebral column and associated muscle, connective tissue, and dermis. The periodicity of somitogenesis is regulated by a segmentation clock of oscillating Notch activity. Here, we examined mouse mutants lacking only Fgf4 or Fgf8, which we previously demonstrated act redundantly to...

Topics

• Animals
• Basic Helix-Loop-Helix Transcription Factors
• Embryo, Mammalian
• Fibroblast Growth Factor 4
• Fibroblast Growth Factor 8
• Gene Expression Regulation
• Gene Expression Regulation, Developmental
• Mice
• Mice, Knockout
• Mice, Transgenic