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Article

Notch signalling and the synchronization of the somite segmentation clock.

Nature - 23 Nov 2000

Jiang Y J, Aerne B L, Smithers L, Haddon C, Ish-Horowicz D, Lewis J

Abstract excerpt

In vertebrates with mutations in the Notch cell-cell communication pathway, segmentation fails: the boundaries demarcating somites, the segments of the embryonic body axis, are absent or irregular. This phenotype has prompted many investigations, but the role of Notch signalling in somitogenesis remains mysterious. Somite patterning is thought to be governed by a "clock-and-wavefront" mechanism: a biochemical...

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Identifiers

PMID: 11100729
DOI: 10.1038/35044091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch signalling and the synchronization of the somite segmentation clock.PMID 11100729Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries.Semantic proximity Read ↗

Deciphering the somite segmentation clock: beyond mutants and morphants.Semantic proximity Read ↗

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Synchrony dynamics during initiation, failure, and rescue of the segmentation clock.Semantic proximity Read ↗

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.Semantic proximity Read ↗

Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.Semantic proximity Read ↗

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

Mutations affecting somite formation in the Medaka (Oryzias latipes).Semantic proximity Read ↗

Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module.Semantic proximity Read ↗

Dynamic expression and essential functions of Hes7 in somite segmentation.Semantic proximity Read ↗

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