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Article

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.

Development (Cambridge, England) - 1 Dec 2001

Sawada A, Shinya M, Jiang Y J, Kawakami A, Kuroiwa A, Takeda H

Abstract excerpt

The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental...

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Identifiers

PMID: 11731466
DOI: 10.1242/dev.128.23.4873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.PMID 11731466Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries.Semantic proximity Read ↗

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.Semantic proximity Read ↗

Involvement of SIP1 in positioning of somite boundaries in the mouse embryo.Semantic proximity Read ↗

Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC.Semantic proximity Read ↗

Somite development in zebrafish.Semantic proximity Read ↗

Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.Semantic proximity Read ↗

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.Semantic proximity Read ↗

PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

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