Article
Dynamic expression and essential functions of Hes7 in somite segmentation.
Genes & development - 15 Oct 2001
Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R
Abstract excerpt
The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior-posterior polarity is disrupted. As a result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although...
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