Article
Dynamic expression and essential functions of Hes7 in somite segmentation.
Genes & development - 15 Oct 2001
Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R
Abstract excerpt
The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior-posterior polarity is disrupted. As a result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cleavage Stage, Ovum
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genetic Vectors
- Glycosyltransferases
- Helix-Loop-Helix Motifs
- In Situ Hybridization
- Lac Operon