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Article

Role of survivin phosphorylation by aurora B in mitosis.

Cell cycle (Georgetown, Tex.) - 1 Aug 2007

Delacour-Larose Marlène, Thi My-Nhung Hoang, Dimitrov Stefan, Molla Annie

Abstract excerpt

The chromosomal protein passenger complex, a key mitotic regulator, consists of at least four proteins, INCENP, Aurora B, Survivin and Borealin. Survivin, in contrast to the other members of the chromosomal protein passenger complex (CPC), is mobile at metaphase. This protein is also phosphorylated by Aurora B at Threonine 117. In this work we have studied the role of the phosphorylation of Survivin in mitosis by...

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Share to Centromere
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17671419
DOI: 10.4161/cc.6.15.4482
PMCID: PMC3323923

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of survivin phosphorylation by aurora B in mitosis.PMID 17671419Read ↗

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Role of Survivin in cytokinesis revealed by a separation-of-function allele.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.Semantic proximity Read ↗

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesionSemantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

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