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Article

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.

The Journal of biological chemistry - 17 Dec 2010

Xu Zhenjie, Vagnarelli Paola, Ogawa Hiromi, Samejima Kumiko, Earnshaw William C

Abstract excerpt

INCENP, Borealin, Survivin, and Aurora B kinase comprise the chromosomal passenger complex, an essential regulator of mitotic events. INCENP (inner centromere protein) binds and activates Aurora B through a feedback loop involving phosphorylation of a Thr-Ser-Ser (TSS) motif near the INCENP C terminus. Here, we have examined the role of the TSS motif in vertebrate cells using an DT40 INCENP(ON/OFF) conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

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Source

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Identifiers

PMID: 20956539
DOI: 10.1074/jbc.M110.181545
PMCID: PMC3000998

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.PMID 20956539Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis.Semantic proximity Read ↗

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.Semantic proximity Read ↗

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