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Article

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.

Current biology : CB - 5 Jun 2001

Wheatley S P, Carvalho A, Vagnarelli P, Earnshaw W C

Abstract excerpt

Three lines of investigation have suggested that interactions between Survivin and the chromosomal passenger proteins INCENP and Aurora-B kinase may be important for mitotic progression. First, interference with the function of Survivin/BIR1, INCENP, or Aurora-B kinase leads to similar defects in...

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Source

Identifiers

PMID: 11516652
DOI: 10.1016/s0960-9822(01)00238-x

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11516652-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.PMID 11516652Read ↗

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.Semantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.Semantic proximity Read ↗

Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesionSemantic proximity Read ↗

INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.Semantic proximity Read ↗

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