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Article

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

The Journal of cell biology - 19 Jul 2004

Gassmann Reto, Carvalho Ana, Henzing Alexander J, Ruchaud Sandrine, Hudson Damien F, Honda Reiko, Nigg Erich A, Gerloff Dietlind L, Earnshaw William C

Abstract excerpt

The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Boreali...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15249581
DOI: 10.1083/jcb.200404001
PMCID: PMC2172304

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15249581-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.PMID 15249581Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development.Semantic proximity Read ↗

Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis.Semantic proximity Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

The chromosomal passenger complex: one for all and all for one.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-BSemantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesionSemantic proximity Read ↗

Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.Semantic proximity Read ↗

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