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Article

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.

Biochemical and biophysical research communications - 28 Jul 2006

Cao Lihuan, Yan Xiaomei, Wu Yanhua, Hu Hairong, Li Qiang, Zhou Tong, Jiang Songmin, Yu Long

Abstract excerpt

Survivin is associated with Aurora B, inner centromere protein (INCENP), and borealin to form a chromosomal passenger complex that plays multiple roles during cell division. We used mutational analysis to study interaction of Survivin with Aurora B and the effect of this interaction on cell division. A Survivin mutant with the terminal domain deleted (Survivin 1-107) bound Aurora B as efficiently as Survivin wild...

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Source

Identifiers

PMID: 16762323
DOI: 10.1016/j.bbrc.2006.05.131

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.PMID 16762323Read ↗

Role of survivin phosphorylation by aurora B in mitosis.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.Semantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Survivin study: an update of "what is the next wave"?Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.Semantic proximity Read ↗

Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell.Semantic proximity Read ↗

Aurora C is directly associated with Survivin and required for cytokinesis.Semantic proximity Read ↗

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