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Article

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

Science (New York, N.Y.) - 8 Oct 2010

Wang Fangwei, Dai Jun, Daum John R, Niedzialkowska Ewa, Banerjee Budhaditya, Stukenberg P Todd, Gorbsky Gary J, Higgins Jonathan M G

Abstract excerpt

Aurora B is a component of the chromosomal passenger complex (CPC) required for correct spindle-kinetochore attachments during chromosome segregation and for cytokinesis. The chromatin factors that recruit the CPC to centromeres are unknown, however. Here we show that phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin...

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Source

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Identifiers

PMID: 20705812
DOI: 10.1126/science.1189435
PMCID: PMC2967368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.PMID 20705812Read ↗

Two histone marks establish the inner centromere and chromosome bi-orientation.Semantic proximity Read ↗

Role of survivin phosphorylation by aurora B in mitosis.Semantic proximity Read ↗

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A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.Semantic proximity Read ↗

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.Semantic proximity Read ↗

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cellsSemantic proximity Read ↗

SUMOylation modulates the function of Aurora-B kinase.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Aurora B regulates MCAK at the mitotic centromere.Semantic proximity Read ↗

H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosisSemantic proximity Read ↗

Control of MCAK degradation and removal from centromeres.Semantic proximity Read ↗

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