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Article

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.

Cell cycle (Georgetown, Tex.) - 15 May 2007

Wheatley Sally P, Barrett Rachel M, Andrews Paul D, Medema Rene H, Morley Simon J, Swedlow Jason R, Lens Susanne M A

Abstract excerpt

Survivin operates in a complex with aurora B kinase and is phosphorylated by it on threonine 117 in vitro. Here we ask whether phosphorylation of survivin by aurora B kinase regulates its function during mitosis in vivo. Using a phospho-specific antibody we first establish that survivin is phosphorylated at T117 during mitosis and is present at the midbody during cytokinesis. Next we use two independent RNAi...

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Source

Identifiers

PMID: 17457057
DOI: 10.4161/cc.6.10.4179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phosphorylation by aurora-B negatively regulates survivin function during mitosis.PMID 17457057Read ↗

Role of survivin phosphorylation by aurora B in mitosis.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.Semantic proximity Read ↗

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Liaisons between survivin and Plk1 during cell division and cell death.Semantic proximity Read ↗

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity.Semantic proximity Read ↗

Functional analysis of Survivin in spindle assembly in Xenopus egg extracts.Semantic proximity Read ↗

Role of Survivin in cytokinesis revealed by a separation-of-function allele.Semantic proximity Read ↗

Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.Semantic proximity Read ↗

[Effect of Plk1 330/597 serine phosphorylated mutant on cytokinesis during mitosis].Semantic proximity Read ↗

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