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Article

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

The Journal of biological chemistry - 13 Feb 2004

Wheatley Sally P, Henzing Alexander J, Dodson Helen, Khaled Walid, Earnshaw William C

Abstract excerpt

The chromosomal passengers, aurora-B kinase, inner centromere protein (INCENP), and survivin, are essential proteins that have been implicated in the regulation of metaphase chromosome alignment, spindle checkpoint function, and cytokinesis. All three share a common pattern of localization, and i...

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Source

Identifiers

PMID: 14610074
DOI: 10.1074/jbc.M311299200

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14610074-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.PMID 14610074Read ↗

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.Semantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

Role of survivin phosphorylation by aurora B in mitosis.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.Semantic proximity Read ↗

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.Semantic proximity Read ↗

Two histone marks establish the inner centromere and chromosome bi-orientation.Semantic proximity Read ↗

Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

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