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Article

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

Molecular biology of the cell - 1 Aug 2003

Honda Reiko, Körner Roman, Nigg Erich A

Abstract excerpt

The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis, respectively. Herein, we have investigated the regulation of human Aurora B by its complex partners inner centromere protein (INCENP) and survivin. We found that overexpression of a catalytically inactive, dominant-negative mutant of Aurora B impaired the localization of the entire...

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Source

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Identifiers

PMID: 12925766
DOI: 10.1091/mbc.e02-11-0769
PMCID: PMC181570

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.PMID 12925766Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.Semantic proximity Read ↗

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.Semantic proximity Read ↗

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cellsSemantic proximity Read ↗

Roles of Aurora kinases in mitosis and tumorigenesis.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

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