Article
Allele-specific peptide presentation of human leukocyte antigens: implications for tumor immunotherapy.
Anticancer research - 1 Jan 2000
Elsner Holger-Andreas, Eiz-Vesper Britta, Blasczyk Rainer, Bade-Döding Christina
Abstract excerpt
BACKGROUND: Human leukocyte antigen (HLA) class I plays a central role in the immune defense against microbes and tumors by presenting endogenously processed peptides to T-cells. Few studies have addressed the question as to what extent variants of the same allelic HLA group differ in their peptide motif. MATERIALS AND METHODS: To answer this question for the HLA-A*66 family, which is a sub-group of the...
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