Article
The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing.
The Journal of experimental medicine - 15 Jan 2001
Brickner A G, Warren E H, Caldwell J A, Akatsuka Y, Golovina T N, Zarling A L, Shabanowitz J, Eisenlohr L C, Hunt D F, Engelhard V H, Riddell S R
Abstract excerpt
Minor histocompatibility antigens (mHAgs) present a significant impediment to organ and bone marrow transplantation between HLA-identical donor and recipient pairs. Here we report the identification of a new HLA-A*0201-restricted mHAg, HA-8. Designation of this mHAg as HA-8 is based on the nomenclature of Goulmy (Goulmy, E. 1996. Curr. Opin. Immunol. 8:75-81). This peptide, RTLDKVLEV, is derived from KIAA0020, a...
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