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Article

HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain.

Human immunology - 1 Jun 2018

Celik Alexander A, Simper Gwendolin S, Huyton Trevor, Blasczyk Rainer, Bade-Döding Christina

Abstract excerpt

The trade-off from HLA class I expression to HLA-G expression support the immune evasion of malignant cells. The essential role of the virtually invariant HLA-G in immune tolerance, tumor immunology and its expression frequency in immune privileged tissues is known; however the specific importance of allelic subtypes in immune responses is still not well understood. HLA-G∗01:01, ∗01:03 and ∗01:04 are the most...

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Source

Identifiers

PMID: 29605689
DOI: 10.1016/j.humimm.2018.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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