Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules.

doi:10.1038/351290a0

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Article

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules.

Nature - 23 May 1991

Falk K, Rötzschke O, Stevanović S, Jung G, Rammensee H G

Abstract excerpt

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information ab...

Topics

Alleles
Amino Acid Sequence
Animals
Chromatography, High Pressure Liquid
Epitopes
Gene Products, gag
H-2 Antigens
HIV
HLA-A2 Antigen
Macromolecular Substances
Major Histocompatibility Complex
Molecular Sequence Data
Peptides
Sequence Homology, Nucleic Acid

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