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Article

Unraveling a hotspot for TCR recognition on HLA-A2: evidence against the existence of peptide-independent TCR binding determinants.

Journal of molecular biology - 28 Oct 2005

Gagnon Susan J, Borbulevych Oleg Y, Davis-Harrison Rebecca L, Baxter Tiffany K, Clemens John R, Armstrong Kathryn M, Turner Richard V, Damirjian Marale, Biddison William E, Baker Brian M

Abstract excerpt

T cell receptor (TCR) recognition of peptide takes place in the context of the major histocompatibility complex (MHC) molecule, which accounts for approximately two-thirds of the peptide/MHC buried surface. Using the class I MHC HLA-A2 and a large panel of mutants, we have previously shown that surface mutations that disrupt TCR recognition vary with the identity of the peptide. The single exception is Lys66 on...

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Identifiers

PMID: 16197958
DOI: 10.1016/j.jmb.2005.08.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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