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Article

Inferring somatic mutation rates using the stop-enhanced green fluorescent protein mouse.

Genetics - 1 Sept 2007

Ro Simon, Rannala Bruce

Abstract excerpt

A new method is developed for estimating rates of somatic mutation in vivo. The stop-enhanced green fluorescent protein (EGFP) transgenic mouse carries multiple copies of an EGFP gene with a premature stop codon. The gene can revert to a functional form via point mutations. Mice treated with a potent mutagen, N-ethyl-N-nitrosourea (ENU), and mice treated with a vehicle alone are assayed for mutations in liver...

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Identifiers

PMID: 17603123
DOI: 10.1534/genetics.106.069310
PMCID: PMC2013726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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