Article
Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.
Genome research - 1 Aug 2015
Uchimura Arikuni, Higuchi Mayumi, Minakuchi Yohei, Ohno Mizuki, Toyoda Atsushi, Fujiyama Asao, Miura Ikuo, Wakana Shigeharu, Nishino Jo, Yagi Takeshi
Abstract excerpt
The germline mutation rate is an important parameter that affects the amount of genetic variation and the rate of evolution. However, neither the rate of germline mutations in laboratory mice nor the biological significance of the mutation rate in mammalian populations is clear. Here we studied genome-wide mutation rates and the long-term effects of mutation accumulation on phenotype in more than 20 generations...
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