Article
Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues.
Mutagenesis - 1 Sept 1994
Douglas G R, Gingerich J D, Gossen J A, Bartlett S A
Abstract excerpt
As a critical step in determining whether transgenic mouse gene mutation systems are suitable models for the detection and quantification of induced gene mutations in vivo, spontaneous mutant frequencies and mutation spectra have been characterized for liver, bone marrow, and male germ cells of the lacZ transgenic mouse strain 40.6. The lacZ transgene is carried on a recombinant bacteriophage lambda shuttle...
Topics
- Amino Acid Sequence
- Animals
- Bacteriophage lambda
- Base Sequence
- Bone Marrow
- DNA
- Genetic Complementation Test
- Genetic Vectors
- Germ-Line Mutation
- Lac Operon
- Liver
- Male