Article
ENU-induced phenovariance in mice: inferences from 587 mutations.
BMC research notes - 24 Oct 2012
Arnold Carrie N, Barnes Michael J, Berger Michael, Blasius Amanda L, Brandl Katharina, Croker Ben, Crozat Karine, Du Xin, Eidenschenk Celine, Georgel Philippe, Hoebe Kasper, Huang Hua, Jiang Zhengfan, Krebs Philippe, La Vine Diantha, Li Xiaohong, Lyon Stephen, Moresco Eva Marie Y, Murray Anne R, Popkin Daniel L, Rutschmann Sophie, Siggs Owen M, Smart Nora G, Sun Lei, Tabeta Koichi, Webster Victoria, Tomisato Wataru, Won Sungyong, Xia Yu, Xiao Nengming, Beutler Bruce
Abstract excerpt
BACKGROUND: We present a compendium of N-ethyl-N-nitrosourea (ENU)-induced mouse mutations, identified in our laboratory over a period of 10 years either on the basis of phenotype or whole genome and/or whole exome sequencing, and archived in the Mutagenetix database. Our purpose is threefold: 1) to formally describe many point mutations, including those that were not previously disclosed in peer-reviewed...
Topics
- Alleles
- Animals
- Databases, Genetic
- Ethylnitrosourea
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mutagens