Article
Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types.
Environmental and molecular mutagenesis - 1 Jan 2004
Hill Kathleen A, Buettner Victoria L, Halangoda Asanga, Kunishige Makoto, Moore Stephen R, Longmate Jeffrey, Scaringe William A, Sommer Steve S
Abstract excerpt
Transgenic mouse mutation detection systems permit rapid determination of the frequency and type of mutations allowing direct examination of mutational markers for aging, neurodegeneration, and cancer. The Big Blue transgenic mouse mutation detection system was used to determine the frequency and nature of spontaneous mutations versus age in multiple tissue types. Nuclear DNA was extracted from whole fetus at...
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