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Article

Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type.

Environmental and molecular mutagenesis - 1 Jan 1996

Nishino H, Buettner V L, Haavik J, Schaid D J, Sommer S S

Abstract excerpt

A lacI-containing transgenic mouse mutation detection system (Big Blue) was used to determine the frequency and spectrum of spontaneous mutation in two rapidly dividing tissues (male germ cells and thymus) and one slowly dividing tissue (brain) at 3 and 10 months of age. By screening 9.4 million...

Topics

Age Factors
Animals
Base Sequence
Brain
Cell Division
DNA Transposable Elements
Female
Male
Mice
Mice, Transgenic
Models, Genetic
Molecular Sequence Data
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Reproducibility of Results

Sequence Deletion

Sex Factors

Spermatozoa

Source

Identifiers

PMID: 8991057
DOI: 10.1002/(SICI)1098-2280(1996)28:4<299::AID-EM2>3.0.CO;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8991057-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type.PMID 8991057Read ↗

Spontaneous mutation in lacI transgenic mice: a comparison of tissues.Semantic proximity Read ↗

Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types.Semantic proximity Read ↗

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice.Semantic proximity Read ↗

Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice.Semantic proximity Read ↗

Spontaneous tandem-base mutations (TBM) show dramatic tissue, age, pattern and spectrum specificity.Semantic proximity Read ↗

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system.Semantic proximity Read ↗

Spontaneous microdeletions and microinsertions in a transgenic mouse mutation detection system: analysis of age, tissue, and sequence specificity.Semantic proximity Read ↗

Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice.Semantic proximity Read ↗

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.Semantic proximity Read ↗

p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.Semantic proximity Read ↗

Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues.Semantic proximity Read ↗

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.Semantic proximity Read ↗

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