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Article

Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistance.

Genome research - 1 Aug 2007

Wang Chunlin, Mitsuya Yumi, Gharizadeh Baback, Ronaghi Mostafa, Shafer Robert W

Abstract excerpt

The detection of mutant spectra within a population of microorganisms is critical for the management of drug-resistant infections. We performed ultra-deep pyrosequencing to detect minor sequence variants in HIV-1 protease and reverse transcriptase (RT) genes from clinical plasma samples. We estimated empirical error rates from four HIV-1 plasmid clones and used them to develop a statistical approach to...

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Source

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Identifiers

PMID: 17600086
DOI: 10.1101/gr.6468307
PMCID: PMC1933516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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