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Article

Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data.

BMC genomics - 24 Mar 2015

Orton Richard J, Wright Caroline F, Morelli Marco J, King David J, Paton David J, King Donald P, Haydon Daniel T

Abstract excerpt

BACKGROUND: RNA viruses have high mutation rates and exist within their hosts as large, complex and heterogeneous populations, comprising a spectrum of related but non-identical genome sequences. Next generation sequencing is revolutionising the study of viral populations by enabling the ultra deep sequencing of their genomes, and the subsequent identification of the full spectrum of variants within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25886445
DOI: 10.1186/s12864-015-1456-x
PMCID: PMC4425905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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