Article
Deep sequencing of HIV: clinical and research applications.
Annual review of genomics and human genetics - 1 Jan 2014
Chabria Shiven B, Gupta Shaili, Kozal Michael J
Abstract excerpt
Human immunodeficiency virus (HIV) exhibits remarkable diversity in its genomic makeup and exists in any given individual as a complex distribution of closely related but nonidentical genomes called a viral quasispecies, which is subject to genetic variation, competition, and selection. This viral diversity clinically manifests as a selection of mutant variants based on viral fitness in treatment-naive...
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