Error rates, PCR recombination, and sampling depth in HIV-1 whole genome deep sequencing.

doi:10.1016/j.virusres.2016.12.009

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Article

Error rates, PCR recombination, and sampling depth in HIV-1 whole genome deep sequencing.

Virus research - 15 Jul 2017

Zanini Fabio, Brodin Johanna, Albert Jan, Neher Richard A

Abstract excerpt

Deep sequencing is a powerful and cost-effective tool to characterize the genetic diversity and evolution of virus populations. While modern sequencing instruments readily cover viral genomes many thousand fold and very rare variants can in principle be detected, sequencing errors, amplification biases, and other artifacts can limit sensitivity and complicate data interpretation. For this reason, the number of...

Topics

Computational Biology
Genetic Variation
Genome, Viral
Genotype
HIV Infections
HIV-1
Humans
INDEL Mutation
Polymerase Chain Reaction
Recombination, Genetic
Reproducibility of Results

Source

Open in PubMed

Identifiers

PMID: 28039047
DOI: 10.1016/j.virusres.2016.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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