Article
Ultra-deep mutant spectrum profiling: improving sequencing accuracy using overlapping read pairs.
BMC genomics - 12 Feb 2013
Chen-Harris Haiyin, Borucki Monica K, Torres Clinton, Slezak Tom R, Allen Jonathan E
Abstract excerpt
BACKGROUND: High throughput sequencing is beginning to make a transformative impact in the area of viral evolution. Deep sequencing has the potential to reveal the mutant spectrum within a viral sample at high resolution, thus enabling the close examination of viral mutational dynamics both within- and between-hosts. The challenge however, is to accurately model the errors in the sequencing data and differentiate...
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