Article
Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing.
Journal of virology - 1 Nov 2010
Bimber Benjamin N, Dudley Dawn M, Lauck Michael, Becker Ericka A, Chin Emily N, Lank Simon M, Grunenwald Haiying L, Caruccio Nicholas C, Maffitt Mark, Wilson Nancy A, Reed Jason S, Sosman James M, Tarosso Leandro F, Sanabani Sabri, Kallas Esper G, Hughes Austin L, O'Connor David H
Abstract excerpt
Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian immunodeficiency virus (HIV/SIV) infection. Minor viral variants have important implications for drug resistance, receptor tropism, and immune evasion. Here, we used ultradeep pyrosequencing to sequence complete HIV/SIV genomes, detecting variants present at a frequency as low as 1%. This approach provides a more complete...
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