Comparison of HIV-1 drug-resistance genotyping by ultra-deep sequencing and sanger sequencing using clinical samples.

doi:10.1002/jmv.24872

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Article

Comparison of HIV-1 drug-resistance genotyping by ultra-deep sequencing and sanger sequencing using clinical samples.

Journal of medical virology - 1 Nov 2017

Trabaud Mary-Anne, Icard Vinca, Ramière Christophe, Tardy Jean-Claude, Scholtes Caroline, André Patrice

Abstract excerpt

Sanger population sequencing (SPS) is the reference technique to monitor HIV-1-infected patients' therapy. Ultra-deep sequencing (UDS), which allows quantitative detection of drug resistance mutations, may be an alternative method. The study aimed to compare reproducibility and predictions of UDS versus SPS in a routine setting. A control containing low-abundance variants was repeatedly tested and clinical plasma...

Topics

Anti-HIV Agents
Drug Resistance, Viral
Female
Genotype
Genotyping Techniques
HIV Infections
HIV-1
High-Throughput Nucleotide Sequencing
Humans
Male
Mutation
Reproducibility of Results
Software
Viral Load

Source

Open in PubMed

Identifiers

PMID: 28590068
DOI: 10.1002/jmv.24872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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