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Article

In vitro selection and characterization of human immunodeficiency virus type 1 resistant to Zidovudine and tenofovir.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2007

Park S-S, Hong S-K, Lee S-G, Yoon J-S, Yoo W-C, Paik S-Y

Abstract excerpt

In this study, we undertook to generate HIV-1 resistance to PMPA by in vitro passage and to characterize the cross-resistance patterns and RT mutations in the generated resistant virus. The HIV-1 A102-resistant to AZT was serially passaged for 4 months in the presence of increasing concentrations of PMPA up to maximum of 40 microM on the fresh MT-2 cells. After 25 passages, HIV-1 developed decreased sensitivity...

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Source

Identifiers

PMID: 17578743
DOI: 10.1080/15257770701426203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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