Article
In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor.
Antiviral research - 1 Jun 2006
Sato Akihiko, Hammond Jennifer, Alexander Therese N, Graham Joanne P, Binford Susan, Sugita Ken-Ichi, Sugimoto Hirohiko, Fujiwara Tamio, Patick Amy K
Abstract excerpt
Capravirine (CPV; formerly AG1549 and S-1153) is a novel, nonnucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) that has demonstrated potent in vitro antiviral activity against several HIV-1 laboratory strains and clinical isolates with EC50 values r...
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