Article
In vitro study of resistance-associated genotypic mutations to nucleoside analogs.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2000
Gashnikova N, Plyasunova O, Kiseleva Y, Fedyuk N, Pokrovsky A
Abstract excerpt
In spite of a rather long period of investigations, the problem of HIV drug resistance remains unsolved, and more that, at present HIV-1 mutants resistant to all known nucleoside inhibitors being used in clinical therapy against the human immunodeficiency syndrome are discovered. In this study we selected HIV-1 mutants resistant to the nucleoside inhibitors of HIV reverse transcriptase (NRTI):...
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