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Article

Generation of multiple drug resistance by sequential in vitro passage of the human immunodeficiency virus type 1.

Archives of virology - 1 Jan 1994

Gao Q, Gu Z, Salomon H, Nagai K, Parniak M A, Wainberg M A

Abstract excerpt

We have sequentially passaged both laboratory and clinical isolates of the human immunodeficiency virus type 1 (HIV-1) in MT-4 cells in the presence of increasing concentrations of different drugs to derive viral variants that are multiply resistant to various combinations of ddC, ddI, d4T and AZT. The EC50 values obtained for the viruses thus generated varied between 50-100 times above those of parental...

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PMID: 8002779
DOI: 10.1007/BF01538821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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