In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.

doi:10.1128/JVI.66.1.12-19.1992

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Article

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.

Journal of virology - 1 Jan 1992

Gao Q, Gu Z X, Parniak M A, Li X G, Wainberg M A

Abstract excerpt

Drug-resistant variants of human immunodeficiency virus type 1 (HIV-1) have been isolated by in vitro selection. MT-4 cells were infected with either a laboratory strain (HIV-IIIB) or a clinical isolate (no. 187) of HIV-1 and maintained in medium containing subeffective concentrations of the drugs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). By gradually increasing the drug concentration in...

Topics

Base Sequence
Cell Line
Cloning, Molecular
DNA, Viral
Didanosine
Drug Resistance, Microbial
HIV-1
Humans
Immunoblotting
Kinetics
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Polymerase Chain Reaction

Viral Proteins

Virus Replication

Zidovudine

Source

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Identifiers

PMID: 1727474
DOI: 10.1128/JVI.66.1.12-19.1992
PMCID: PMC238254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1727474-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.PMID 1727474Read ↗

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