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Article

3'-Azido-3'-deoxythymidine (AZT) mediates cross-resistance to nucleoside analogs in the case of AZT-resistant human immunodeficiency virus type 1 variants.

Journal of virology - 1 Jun 1998

Arts E J, Quiñones-Mateu M E, Albright J L, Marois J P, Hough C, Gu Z, Wainberg M A

Abstract excerpt

Difficulties in deciphering the mechanisms of 3'-azido-3'-deoxythymidine (AZT)-resistance by human immunodeficiency virus type 1 (HIV-1) variants are due in part to an inability to reconstitute resistance in vitro using AZT-resistant reverse transcriptases. We decided to characterize mechanisms of AZT resistance in tissue culture infections by studying the ability of drug-resistant viruses to synthesize viral DNA...

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Identifiers

PMID: 9573252
DOI: 10.1128/JVI.72.6.4858-4865.1998
PMCID: PMC110035

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