Generation of nucleoside-resistant variants of HIV-1 by in vitro selection in the presence of AZT or DDI but no by combinations.

Article

Generation of nucleoside-resistant variants of HIV-1 by in vitro selection in the presence of AZT or DDI but no by combinations.

Leukemia - 1 Jan 1992

Gao Q, Parniak M A, Gu Z, Wainberg M A

Abstract excerpt

Several laboratories have shown that AZT-resistant variants of HIV-1 can be isolated from patients who have received prolonged therapy with this drug. Our laboratory has now been able to generate HIV-1 variants resistant to both AZT and ddI, in tissue culture, by using step-wise increases in the...

Topics

Amino Acid Sequence
Didanosine
Drug Combinations
Drug Resistance, Microbial
HIV-1
Humans
Interferon alpha-2
Interferon-alpha
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Recombinant Proteins
Zidovudine

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