Article
Natural resistance of human immunodeficiency virus type 2 to zidovudine.
Virology - 5 Jun 2005
Reid Patrick, MacInnes Hamish, Cong Mian-Er, Heneine Walid, García-Lerma J Gerardo
Abstract excerpt
Zidovudine (AZT) is a reverse transcriptase (RT) inhibitor widely used to treat persons infected with HIV-1 and HIV-2. Recent data on treated patients suggest differences in the antiviral activity of AZT between HIV-1 and HIV-2. We evaluated the antiviral activity of AZT on HIV-2 by using multiple approaches including in vitro selection experiments, analysis of growth kinetics with AZT, and phenotypic testing. A...
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