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Article

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.

Journal of virology - 1 Apr 1995

Patick A K, Rose R, Greytok J, Bechtold C M, Hermsmeier M A, Chen P T, Barrish J C, Zahler R, Colonno R J, Lin P F

Abstract excerpt

Development of viral resistance to the aminodiol human immunodeficiency virus (HIV) protease inhibitor BMS 186,318 was studied by serial passage of HIV type 1 RF in MT-2 cells in the presence of increasing concentrations of compound. After 11 passages, an HIV variant that showed a 15-fold increas...

Topics

Amino Acid Sequence
Base Sequence
Carbamates
Cell Line
DNA Primers
Drug Resistance, Microbial
Ethanolamines
Genetic Variation
HIV Protease
HIV Protease Inhibitors
HIV-1
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Sequence Homology, Amino Acid

Serial Passage

Source

Open in PubMed Open full text

Identifiers

PMID: 7884862
DOI: 10.1128/JVI.69.4.2148-2152.1995
PMCID: PMC188882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7884862-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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